The influence of age, comorbidity and frailty on treatment with surgery and systemic therapy in older women with operable triple negative breast cancer (TNBC) in England: A population-based cohort study

Background Surgery and chemotherapy use were studied among older women with early stage triple negative breast cancer (TNBC) in a population-based cohort. Methods Women aged ?50 years unilateral (stage 1-3a) TNBC diagnosed 2014–2017 identified from English registration data. Information on surgery was linked Hospital Episode Statistics Systemic Anti-Cancer Therapy datasets, respectively. Logistic regression used to investigate the influences of patient age, comorbidity frailty uptake chemotherapy. Results There 7094 TNBC. Overall rate 94%, which only decreased ?85 (74%) most frail. Among 6681 receiving surgery, 16% had neoadjuvant 42% adjuvant chemotherapy; both age. More comorbidities greater associated lower rates differences across geographical regions regimens between age groups. Conclusion Majority although some physically fit did not. Chemotherapy varied by fitness.